A few years have passed since the cliff hanger conclusion of Tom Clancy's Splinter Cell: Double Agent, in which Agent Sam Fisher undertook a particularly dirty mission, full of questionable actions, in the shadow of the inexplicable and unmourned death of his daughter. Fisher is now a renegade operative digging into the events of the past and he doesn't like what he has found. His personal investigation into his daughter's death reveals that he's been betrayed by his former agency, the Third Echelon. The agency responds by pursuing him, but as he works to elude them he becomes aware of a deadly terrorist plot that threatens millions. He is uniquely positioned and prepared to act against this, but success is doubtful without the help of former friends from the Third Echelon team, resulting in a series of life and death situations for himself and the country where trust can by no means be assumed.